現在行っている研究

● 新型コロナウイルス（SARS-CoV-2）のシークエンスとコピー数の解析（R-50-12J）
●家族性発症が見られる甲状腺腫の遺伝的要因の解析（R-54-5J）
●甲状腺刺激ホルモンイムノアッセイ試薬のハーモナイゼーション-甲状腺疾患患者からの血液検体採
　 取（IFCC TSH スタディ）（R-54-6J）
●甲状腺濾胞癌の原発腫瘍におけるHMGA2の発現と転移再発予測（R-62-18J)
●腹圧性尿失禁および骨盤内臓器脱が疑われる女性患者における骨盤臓器脱定量(pelvic organ prolapse
　 quantification:POP-Q)システムおよびPOP-Q stage分類による骨盤内臓　器脱評価法と下部尿路症状
　および障害との関連性に関する新規探索法について（Ｒ-64-4Ｊ）

業績

主な著書

  • Regulation and Enhancement of Endogenous Sodium Iodide Symporter　Expression: NIS Regulatory Pathways in Thyroid and Breast Cancer.Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects. Academic Press 2009
  • Thyroid Hormones (T4, T3)
    Endocrinology: Basic and Clinical Principles. Humana Press 2005

主な原著論文

  • Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.J Biol Chem. 287: 3292-300, 2012
  • Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8).J Biol Chem. 285: 27279-88, 2010
  • Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells.J Endocrinol. 199: 243-52, 2008
  • Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways.J Clin Endocrinol Metab. 93: 1884-92, 2008
  • Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase.Microbes Infect 9: 1410-1414, 2007
  • Relationship between the initial dose of micafungin and its efficacy in patients with candidemia.J Infect Chemother 13:208-212, 2007
  • Macrophage tolerance induced by stimulation with Toll-like receptor 7/8 ligands.Immunol Lett 111:51-56, 2007
  • Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells.Endocrinology. 146: 3059-69, 2005
  • Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models.Cancer Res. 64: 415-22, 2004
  • The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.Breast Cancer Res Treat. 78: 119-26, 2003
  • Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells.Endocrinology. 142: 3369-79, 2001
  • Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line.Proc Natl Acad Sci U S A. 97: 8519-24, 2000
  • Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells.Endocrinology. 138: 2227-32, 1997

総説

  • Sodium iodide symporter in the fight against thyroid cancer.Future Oncol. 9: 1679-82, 2013
  • Cancer: Novel target to enhance radioiodine uptake in thyroid cancer.Nat Rev Endocrinol. 9: 508-9, 2013
  • The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics.
    Pharmacol Ther. 135: 355-70, 2012
  • Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.Endocr Relat Cancer.　 13: 797-826, 2006